Cerebral Palsy and Regenerative Medicine ©

By David Steenblock, M.S., D.O.

"The obstacle is the path." Zen Proverb

Astrup, J., Symon, L, Branston, NM, Lassen NA. “Cortical evoked potential and extracellular K+ and H+ at critical levels of brain ischemia.” Stroke, 1977; 8: 51-57.

Astrup, J. Siesjo, BK, Symon L. AThresholds in Cerebral Ischaemia-the ischaemic penumbra.@ STROKE 1981: 12:723-5.

Avice, M N; Rubio, M; Sergerie, M; Delespesse, G; Sarfati, M. “CD47 ligation selectively inhibits the development of human naive T cells into Th1 effectors”, Journal of Immunology (Baltimore, Md.: 1950), Volume 165, Issue 8, October 15, 2000, Pages 4624-4631

Avice M, Rubio M, Sergerie M, Delespesse G, Sarfati M. “Role of CD47 in the induction of human naive T cell anergy.” J Immunol. 2001 Sep 1;167(5):2459-68.

Barker J, Wagner J. “Umbilical cord blood transplantation: current state of the art.” Curr Opin Oncol 2002, 14: 160-164.

Bartley J, Carroll JE. “Stem Cell Therapy for Cerebral Palsy.” Expert Opin Biol Ther, 2003, 3(4): 541-9.

Bicknese A, Goodwin H, Quinn C, Henderson V, Chien S, Wall D. “Human umbilical cord blood cells can be induced to express markers for neurons and glia.” Cell Transplant 2002; 11(3): 261-4.

Booth A. et al. “Thiamine pyrophosphate and pyridoxamine inhibit the formation of antigenic advanced glycation end-products: comparison with aminoguanidine.” Biochem Biophys Res Comm, 1996; 220: 113-119.

Buschmann IR, Busch HJ, Mies G, Hossmann KA. “Therapeutic Induction of Arteriogenesis in Hypoperfused Rat Brain Via Granulocyte-Macrophage Colony-Stimulating Factor.” Circulation, 2003, June 30.

Chakraborti S, Chakraborti T, Mandal M, Mandal A, Das S, Ghosh S. “Protective role of magnesium in cardiovascular diseases: a review. Mol Cell Biochem 2002 Sep;238(1-2):163-79.

Chatterjee M. “Vitamin D and genomic stability.” Mutat Res 2001 Apr 18;475(1-2):69-87.

Chen J, Sanberg P, Li Y, Wang L, Lu M, Willing A, Sanchez-Ramos J, Chopp M. “Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats.” 2001; 32: 2682-2688.

Chen ST, Chuang JI, Hong MH, Li EI. “Melatonin attenuates MPP+-induced neurodegeneration and glutathione impairment in the nigrostriatal dopaminergic pathway.” J Pineal Res, 2002, 32(4): 262-9.

Clarke SD, Gasperikova D, Nelson C, Lapillonne A, Heird WC. “Fatty acid regulation of gene expression: a genomic explanation for the benefits of the Mediterranean diet.” Ann NY Acad Sci, 2002, 967: 283-98.

Crisa L, Cirulli V, Smith K, Ellisman M, Torbett B, Salomon D. “Human Cord Blood Progenitors Sustain Thymic T-cell development and a novel form of angiogenesis.” Blood, 1999, 94(11): 3928-3940.

Croop J, Cooper R, Fernandex C, Graves V, Kreissman S, Hanenberg H, Smith F, William D. “Mobilization and collection of peripheral blood CD34+ cells from patients with Fanconi anemia.” Blood, 2001; 98: 2917-2921.

De La Monte, S.M. et al. “Mitochondrial DNA damage and impaired mitochondrial function contribute to apoptosis of insulin-stimulated ethanol-exposed neuronal cells.” Alcohol Clin Exp Res, 2001; 25(6): 898-906.

Dluzen DE. “Neuroprotective effects of estrogen upon the nigrostriatal dopaminergic system.” J Neurocytol 2000 May-Jun;29(5-6):387-99

Ende N, Chen R. “Human umbilical cord blood cells ameliorate Huntington’s disease in transgenic mice.” J Med, 2001; 32(3-4): 231-40.

Ende N, Chen R, Ende-Harris D. “Human umbilical cord blood cells ameliorate Alzheimer’s disease in transgenic mice.” J Med, 2001; 32(3-4): 241-7.

Fragata, M, Bellemare F, Nenonen E.K. “Mg (II) Adsorption to a phosphatidylglycerol model membrane studied by Atomic absorption and FT-IR Spectroscopy.” J Phys Chem, 1997; 101: 1916-1921.

Garcion E, Wion-Barbot N, Montero-Menei CN, Berger F, Wion D. New clues about vitamin D functions in the nervous system. Trends Endocrinol Metab, 2002 Apr;13(3):100-5.

Ginsberg MD, Reivich M, Frinak S, Harbig K, APyridine nucleotide redox state and blood flow of the cerebral cortex following middle cerebral artery occlusion in the cat.@ Stroke, 1976, 7:125-131.

Gluckman E, Rocha V, Boyer-Chammard A et al. “Outcome of cord-blood transplantation from related and unrelated donors.” New Engl J Med, 1997; 337: 373-381.

Gowland, C., P. Stratford, M. Ward, J. Moreland, W. Torresin, S.Van Hulle, et al. “Measuring physical impairment and disability with the Chedok McMaster Stroke Assessment.” Stroke, 1993, 24(1): 58-63.

Handgretinger, R, P. Lang, M. Schumm, M. Pfeiffer, S. Gottschling, B. Demirdelen, P. Bader, S. Kuci, T. Klingebiel and D. Niethammer. “Immunological Aspects of Haploidentical Stem Cell Transplantation in Children.” Annals of the New York Academy of Sciences, 2001; 938: 340-358.

Hattori K, Heissig B, Rafii S. “The regulation of hematopoietic stem cell and progenitor mobilization by chemokine SDF-1.” Leuk Lymphoma. 2003 Apr;44(4):575-82.

Heuser G, Heuser S.A., Rodelander D, Aguilera O, Uszler M. “Treatment of Neurologically Impaired Adults and Children with “Mild” Hyperbaric Oxygen (1.3 ATA and 24% Oxygen).” Pp. 109-115. In Joiner J. (ed). The Proceddings of the 2nd International Symposium on Hyperbaric Oxygenation for Cerebral Palsy and the Brain-Injured Child, Best Publishing Company, Flagstaff, Arizona, 2002.

Howard C, Hope J, Stephens S, Gliddon D and Brooke G. “Co-stimulation and modulation of the ensuing immune response”, Veterinary Immunology and Immunopathology, Volume 87, Issues 3-4, 10 September 2002, Pages 123-130

Kao, Race. “Autologous Satellite cells for myocardial regeneration.” E-Biomed, 2001; 2: 1-8.

Katayama Y, Hidalgo A, Furie BC, Vestweber D, Furie B, Frenette PS. “PSGL-1 participates in E-selectin-mediated progenitor homing to bone marrow: evidence for cooperation between E-selectin ligands and {alpha}4 integrin.” Blood. 2003.

Kikurchi M, Kashii S, Honda Y, Tamura Y, Kaneda K, Akaike A. “Protective effects of methylcobalamin, a vitamin B12 analog, against glutamate-induced neurotoxicity in retinal cell culture. Invest Ophthalmol Vis Sci, 1997, 38(5): 848-54.

Kim EH, Jang MH, Shin MC, Lim BV, Kim HB, Kim YJ, Chung JH, Kim CJ. “Acupuncture increases cell proliferation and neuropeptide Y expression in dentate gyrus of streptozotocin-induced diabetic rats.” Neruosci Lett, 2002, 327(1): 33-6.

Kurtzberg J, Laughlin M, Graham M et al. “Placental blood as a source of hematopoietic stem cells for transplantation into unrelated recipients.” New England J Med, 1996; 335: 155-166.

Lee, J.D. et al. “Technetium-99m-ECD brain SPECT in cerebral palsy: comparison with MRI.” Journal of Nuclear Medicine, 39(4): 619-2, 1998.

Limaye LS, Kale V.P. “Cryopreservation of human hematopoietic cells with membrane stabilizers and bioantioxidants as additives in the conventional freezing medium.” .J Hematotherapy and Stem Cell Research, 2001: 10: 709-718.

Lu L, Shen R, Broxmeyer H. “Stem cells from bone marrow, umbilical cord blood and peripheral blood for clinical application: Current status and future application.” Critical Reviews in Oncology/Hematology, 1996; 22: 61-78.

Mattson, Mark. “Amino acid signaling removes and then replaces brain cells.” Trends in Neurosciences, 2001, 24(10): 565-566.

McKeena D.H., Wagner J.E., McCullough J., “Umbilical cord blood infusions are associated with mild reactions and are overall well-tolerated.” Poster Abstract, 9th Annual Meeting of the International Society for Cellular Therapy, May 29-June 1, 2003, Phoenix, Arizona.

Meagher R, Klingemann H. “Human Umbilical cord blood cells: How useful are they for the clinician?” Journal of Hematotherapy and Stem Cell Research, 2002, 1: 445-448.

Mountz JM, Modell JG, Foster NL, et al. APrognostication of recovery following stroke using the comparison of CT and technetium-99 HM-PAO SPECT.@ J Nucl Med 1990; 31:61-66.

Miyamoto Y, Koh YH, Park YS, Fujiwara N, Sakiyama H, Misonou Y, Ookawara T, Suzuki K, Honke K, Taniguchi N. “Oxidative stress caused by inactivation of glutathione peroxidase and adaptive responses.” Bio Chem, 2003, 384(4): 567-74.

Nakagawa T, Tsuchida A, Itakura Y, Nonomura T, Ono M, Hirota F, Inoue T, Nakayama C, Taiji M, Noguchi H. “Brain-derived neurotrophic factor regulates glucose metabolism by modulating energy balance in diabetic mice.” Diabetes 2000 Mar;49(3):436-44.

Nie G, Cao Y, Zhao B. “Protective effects of green tea polyphenols and their major component, (-)-epigallocatechin-3-gallate (EGCG), on 6-hydroxydopamine-induced apoptosis in PC 12 cells.” Redox Rep, 2002; 7(3): 171-7.

Oczkowski, W.J., S. Barreca. “The functional independence measure: its use to identify rehabilitation needs in stroke survivors.” Arch Phys Med Rehabil, 1993; 74(12): 1291-4.

Oi Y, Imafuku M, Shishido C, Kominato Y, Nishimura S, Iwai K. Garlic supplementation increases testicular testosterone and decreases plasma corticosterone in rats fed a high protein diet. J Nutr 2001 Aug;131(8):2150-6

Oldenborg, P A; Zheleznyak, A; Fang, Y F; Lagenaur, C F; Gresham, H D; Lindberg, F P. “Role of CD47 as a marker of self on red blood cells”, Science, 2000; 288 (5473): 2051-2054.

Pahwa R, Fleicher A, Than S, Good R. “Successful hematopoietic reconstitution with transplantation of erythrocyte-depleted allogeneic human umbilical cord blood cells in a child with leukemia.” Proc Natl Acad Sci, 1994; 91: 4485-4488.

Palmer, Theo et al. “Mobilizing Endogenous Stem Cells.” In Rao, M. (ed) STEM CELLS AND CNS DEVELOPMENT, Humana Press, Totowa, New Jersey, 2001, pg. 270.

Paquette R, Dergham S, KarpfE, Wang H, Slamon D, Souza L, Glaspy J. “Ex vivo expanded unselected peripheral blood: progenitor cells reduce post-transplantation neutropenia, thrombocytopenia, and anemia in patients with breast cancer.” Blood, 2000; 96: 2385-2390.

Pecora, AL, Stiff P, LeMaistre, CF. Bayer R, Bachier C, Goldberg SL, Parthasarathy M, Jennis AA, Smith AK, Douville J, Chen B, Armstrong RD, Mandalam RK, Preti R. “A phase II trial evaluating the safety and effectiveness of the Aastrom Replicell system for augmentation of low-dose blood stem cell transplantation.” Bone Marrow Transplant, 2001, 28(3): 295-303.

Persky, AM, Brazeau GA. “Clinical pharmacology of the dietary supplement creatine monohydrate.” Pharmacol Rev, 2001, 53(2): 161-76.

Pettersen, R D. “CD47 and death signaling in the immune system” Apoptosis: an International Journal on Programmed Cell Death, Volume 5, Issue 4, October 2000, Pages 299-306

Pfeifer, R.: AUeber die traumatische Degeneration und Regeneration des Gehirns erwachsener Menschen,@ JOUR F PSYCHOL UL NEUROL, Bd. 1908, 12.

Raynaud C, Rancurel G, Samson Y, Baron JC, Soucy JP, Kieffer E, Cabanis E., Majdalani A, Ricard S, Bardy A, Bourguignon M, Syrota A, Lassen NA (1987) APathophysiologic study of chronic infarcts with I-123 Isopropyl iodo-amphetamine (IMP): The importance of periinfarct area.@ STROKE, 1987, 18: 21-29.

Rogers, I., Casper, RF. “Stem cells: you can’t tell a cell by its cover.” Hum Reprod Update, 2003, 9(1): 25-33.

Rosler, E. Brandt J, Chute J, Hoffman R. “Cocultivation of umbilical cord blood cells with endothelial cells leads to extensive amplification of competent CD34+ CD38- cells.” Exper Hematology, 2000, 28: 841-852.

Rubinstein P, Carrier C. Scaradavou A. et al. “Outcomes among 562 recipients of placental-blood transplants from unrelated donors. New Engl J Med, 1998; 339: 1565-1577.

Rusyniak DE et al. “Hyperbaric oxygen therapy in acute ischemic stroke: results of the hyperbaric oxygen in acute ischemic stroke trial pilot study.” Stroke, 34(2): 571-4, 2003.

Sanchez-Ramos J, Song S, Kamath S, Zigova T, Willing A, Cardozo-Pelaez F, Stedeford T, Chopp M, Sanberg P. “Expression of neural markers in human umbilical cord blood.” Exp Neurology, 2001; 171: 109-115.

Sauer, H. et al. “Effects of electrical fields on cardiomyocyte differentiation of embryonic stem cells.” J Cell Biochem, 1999, 75(4): 710-23.

Schmidt, Christine et al. “Stimulation of neurite outgrowth using an electrically conducting polymer.” Proc Natl Acad Sci, 1997, 94: 8948-8953.

Spadea I, Balestrazzi E. “Treatment of vascular retinopathies with pycnogenol.” Phytotherapy Research, 2001; 15: 219-223.

Stevens, C, Gladstone J, Taylor P, Scaradavon A, Migliaccio A, Visser J, Dobrila N, Carrier C, Cabbad M, Wernet P, Kurtzber J, Rubinstein P. “Placenta/umbilical cord blood for unrelated-donor bone marrow reconstitution: relevance of nucleated red blood cells.” Blood, 2002, 100(7): 2662-2664.

Strong, A.J., G.S. Venables, and G. Gibson. AThe Cortical ischaemic penumbra associated with occlusion of the middle cerebral artery in the cat. 1. Topography of changes in blood flow, potassium ion activity and EEG.@ J CEREB BLOOD FLOW METABOL, 1983, 3:86-96.

Strong, A.J., B.E. Tomlinson,G.S. Venables, G. Gibson, and J.A. Hardy AThe cortical ischemic penumbra associated with occlusion of the middle cerebral artery in the cat. 2. Studies of histopathology, water content and in vitro neurotransmittter uptake.@ J CEREB. BLOOD FLOW METABOL, 1983; 3: 97-108.

Strong, AJ, Miller SA, Venables GS (1987) Tests of corticial vasoregulation in the analysis of diaschisis and early ischaemic change in boundary zones. In: Powers W.J. and M.E. Raichle (eds): CEREBROVASCULAR DISEASES. Proc. Fifteenth Princeton Research Conference, New York, Raven Press, pp. 251-255.

Symon L, N.M. Branston, and A.J. Strong. AAutoregulation in acute focal ischaemia: an experimental study.@ STROKE 1976, 7:547-554.

Sun, Q. Burton R, Pollok K, Emanuel D, Lucas K. “CD4+ Epstein-Barr Virus-specific Cytotoxic T-lymphocytes from Human Umbilical Cord Blood.” Cellular Immunology, 1999, 195: 81-88.

Tefft, Gregory. “For Your Body Only.” Hope for Life, Mission Viejo, CA, 2002.

Tyson GW, Teasdale, GM, Graham, DI, McCulloch J. AFocal cerebral ischaemia in the rat. Topography of hemodynamic and histopathological changes.@ ANN NEUROL, 1984, 15:559-567.

Vuillerme N, Teasdale N, Nougier V. “The effect of expertise in gymnastics on proprioceptive sensory integration in human subjects.” Neurosci Lett, 2001, 311(2): 73-6.

Wadhwa, P, Lazarus H, Koc O, Jaroscak J, Woo D, Stevens C, Rubinstein P, Laughlin M. “Hematopoietic recovery after unrelated umbilical cord-blood allogeneic transplantation in adults treated with in vivo stem cell factor (R-MetHusCF) and filgrastim administration.” Leukemia Research, 2002, Mar;27(3):215-20

Wagner J, Rosenthal J, Sweetman R et al. “Successful transplantation of HLA-matched and HLA-mismatched umbilical cord blood from unrelated donors: analysis of engraftment and acute graft-versus-host disease.” Blood, 1996; 88: 795-802.

Walters, K.C. et al. “Screening for oxygen sensitivity in U.S. Navy combat swimmers.” UNDERSEA HYPERBARIC MED, 2000, Spring, 27(1): 21-6.

Yamada, K. et al. “Brain MRI and single photon emission computed tomography in severe athetotic cerebral palsy: a comparative study with mental and motor disorders.” TO HATTATSU (brain and development), 27(4): 269-75, 1995.

Zhou L, Dosanjh A, Chen H, Karasek M. “Divergent effects of extracellular oxygen on the growth, morphology, and function of human skin microvascular endothelial cells. J Cell Physiol, 2000, 182(1): 134-40.

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